synthesis of nanovectors via functionalization of swnt with pei (polyethyleneimine) for gene delivery
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چکیده
منابع مشابه
PEG-grafted Hyperbranched Polyethyleneimine-Oxidized Single Walled Carbon Nanotube Complex (PEG-PEI-SWNT) for Sustained Delivery of Doxorubicin
To take advantages of single-walled carbon nanotubes (SWNTs) for cellular delivery of chemotherapeutic agents (e.g. doxorubicin) in order to decrease doxorubicin toxicity and increase its efficacy, we aimed to develop a novel approach to aqueous disperse and stabilize SWNTs through consequent steps of oxidation (oxSWNT) and PEG-PEI complexation (PEG-PEI-SWNT). Doxorubicin was loaded onto the mo...
متن کاملOptimization of conditions for gene delivery system based on PEI
Objective(s): PEI based nanoparticle (NP) due to dual capabilities of proton sponge and DNA binding is known as powerful tool for nucleic acid delivery to cells. However, serious cytotoxicity and complicated conditions, which govern NPs properties and its interactions with cells practically, hindered achievement to high transfection efficiency. Here, we have tried to optimize the properties of ...
متن کاملSWNT conductor orchestrates functionalization
Nanoelectronics systems must often be made with a wide variety of disparate materials, but the primary modes of manufacture – epitaxy or mechanical bonding – place stringent requirements on the ultimate scale or constituent materials of circuits. Researchers at the University of Illinois, Urbana-Champaign have developed a method for building twoand threedimensional circuits using a process akin...
متن کاملoptimization of conditions for gene delivery system based on pei
objective(s): pei based nanoparticle (np) due to dual capabilities of proton sponge and dna binding is known as powerful tool for nucleic acid delivery to cells. however, serious cytotoxicity and complicated conditions, which govern nps properties and its interactions with cells practically, hindered achievement to high transfection efficiency. here, we have tried to optimize the properties of ...
متن کاملsingle-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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